Way back after the flood, an angel was supposed to use something in a small box to finish wiping out life on the planet. He lost it and has been looking ever since. Now it's turned up again and several factions are trying to steal it. Most want Coop to steal it for them.
I'm a big fan of Kadrey's other series, Sandman Slim, and this book does have some things in common with them apart from angels. Both series are grizzly-funny. However, the narrative feel is drastically different, in that Sandman Slim is first person and The Everything Box is not only third person but spends a lot of time following people and groups other than Coop. This might be the reason why Kadrey is less successful in making him somebody to whom the reader can connect.
I was put in mind of the paranormal, literary equivalent of a Tarantino heist movie. If that kind of thing sounds good to you, you might want to check this out. Personally, I've never cared much for Tarantino. Considering how many other books I have at the ready when I have a moment between committee books, I won't be bothering with the sequel.